Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

Abstract Background Tumour hypoxia promotes an aggressive tumour phenotype and enhances resistance to anticancer treatments. Following the recent observation that the mitochondrial inhibitor atovaquone increases tumour oxygenation in NSCLC, we sought to assess whether atovaquone affects tumour subre...

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Detalhes bibliográficos

Principais autores:	Pauline Bourigault, Michael Skwarski, Ruth E. Macpherson, Geoff S. Higgins, Daniel R. McGowan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2021-12-01
coleção:	EJNMMI Research
Assuntos:	Non-small cell lung cancer Tumour hypoxia Atovaquone PET FMISO
Acesso em linha:	https://doi.org/10.1186/s13550-021-00871-x
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