Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies

SARS-CoV-2 is a respiratory borne pathogenic beta coronavirus that is the source of a worldwide pandemic and the cause of multiple pathologies in man. The rhesus macaque model of COVID-19 was utilized to test the added benefit of combinatory parenteral administration of two high-affinity anti-SARS-C...

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Principais autores:	Brandon J. Beddingfield, Nicholas J. Maness, Alyssa C. Fears, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, Ann M. Carias, Patrick J. Madden, Ramon Lorenzo Redondo, Hongmei Gao, David Montefiori, Thomas J. Hope, Chad J. Roy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-11-01
coleção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	SARS-CoV-2 SARS-CoV-2 antibodies nonhuman primates immunoprophylaxis pharmacokinetics
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2021.753444/full
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