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A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-E2 receptor EP2 with a small molecule antagonist, delayed by 2–4 h after SE onset. Administration of six doses of...

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Principais autores: Asheebo Rojas, Thota Ganesh, Wenyi Wang, Jennifer Wang, Raymond Dingledine
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-01-01
Serier:Neurobiology of Disease
Fag:
Diisopropyl fluorophosphate
EP2
Albumin
Acetylcholinesterase
Neurodegeneration
Status epilepticus
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996119300427
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