TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia.

TAR DNA-binding protein 43 (TDP-43) dysfunction is a hallmark of several neurodegenerative diseases, including frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer's disease. Although cryptic exon inclusion is a well-characterized consequence of TDP-43 loss of function, emerging evi...

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Principais autores:	Vidhya Maheswari Jawahar, Yi Zeng, Ellen M Armour, Mei Yue, Kathryn Citrano, Anastasiia Lovchykova, Madison M Reeves, Bailey Rawlinson, Michael DeTure, Judith A Dunmore, Yuping Song, Sophie K Ball, Zbigniew K Wszolek, Neill R Graff-Radford, Bradley F Boeve, David S Knopman, Gregory S Day, Scott A Small, Dennis W Dickson, Michael E Ward, Tania F Gendron, Yongjie Zhang, Mercedes Prudencio, Aaron D Gitler, Leonard Petrucelli
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2026-01-01
coleção:	PLoS Biology
Acesso em linha:	https://doi.org/10.1371/journal.pbio.3003573
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