Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells

Patients with digenic S100A3 and S100A13 mutations exhibited an atypical and progressive interstitial pulmonary fibrosis, with impaired intracellular calcium homeostasis and mitochondrial dysfunction. Here we provide direct evidence of a causative effect of the mutation on receptor mediated calcium...

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Principais autores:	Eid A. Al-Mutairy, Somaya Al Qattan, Mohammed Khalid, Azizah A. Al-Enazi, Maher M. Al-Saif, Faiqa Imtiaz, Khushnooda Ramzan, Vineesh Raveendran, Ayodele Alaiya, Brian F. Meyer, Sergei P. Atamas, Kate S. Collison, Khalid S. Khabar, Jeffrey D. Hasday, Futwan Al-Mohanna
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-11-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	lung fibrosis calcium mitochondria S100A3 S100A13
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1282868/full
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