Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
Abstract Poly(ADP-ribose) polymerase 1 (PARP1) detects DNA strand breaks that occur in duplex DNA and chromatin. Here, correlative optical tweezers and fluorescence microscopy reveal how single molecules of PARP1 identify single-strand breaks (i.e., nicks), undamaged nucleosome core particles (NCP)...
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| Principais autores: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2025-12-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-025-67071-2 |
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