Synthesis and In Vitro Cytotoxicity of the 4-(Halogenoanilino)-6-bromoquinazolines and Their 6-(4-Fluorophenyl) Substituted Derivatives as Potential Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase

Series of the 2-unsubstituted and 2-(4-chlorophenyl)–substituted 4-anilino-6-bromoquinazolines and their 6-(4-fluorophenyl)–substituted derivatives were evaluated for in vitro cytotoxicity against MCF-7 and HeLa cells. The 2-unsubstituted 4-anilino-6-bromoquinazolines lacked activity, whereas most o...

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Principais autores:	Malose Jack Mphahlele, Hugues K. Paumo, Yee Siew Choong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2017-11-01
coleção:	Pharmaceuticals
Assuntos:	6-bromo-4-chloroquinazolines amination Suzuki–Miyaura cross-coupling cytotoxicity EGFR-TK molecular docking
Acesso em linha:	https://www.mdpi.com/1424-8247/10/4/87
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