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Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription.

Herpesviruses are ubiquitous pathogens that cause a wide range of disease. Upon nuclear entry, their genomes associate with histones and chromatin modifying enzymes that regulate the progression of viral transcription and outcome of infection. While the composition and modification of viral chromati...

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Autors principals: Ashley P E Roberts, Anne Orr, Victor Iliev, Lauren Orr, Steven McFarlane, Zhousiyu Yang, Ilaria Epifano, Colin Loney, Mila Collados Rodriguez, Anna R Cliffe, Kristen L Conn, Chris Boutell
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2025-08-01
Col·lecció:PLoS Pathogens
Accés en línia:https://doi.org/10.1371/journal.ppat.1012501
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