Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Here, the authors develop a monoclonal antibody that specifically inhibits APC’s anticoagulant function without compromising its cytoprotective function, and shows efficacy in animal models.

Detalhes bibliográficos

Principais autores:	Xiao-Yan Zhao, Andreas Wilmen, Dongli Wang, Xinquan Wang, Maxine Bauzon, Ji-Yun Kim, Lars Linden, Liang Li, Ursula Egner, Tobias Marquardt, Dieter Moosmayer, Jan Tebbe, Julian Marius Glück, Philipp Ellinger, Kirk McLean, Shujun Yuan, Subramanian Yegneswaran, Xiaoqiao Jiang, Vince Evans, Jian-Ming Gu, Doug Schneider, Ying Zhu, Yifan Xu, Cornell Mallari, Ashley Hesslein, Yan Wang, Nicole Schmidt, Katrin Gutberlet, Christine Ruehl-Fehlert, Alexius Freyberger, Terry Hermiston, Chandra Patel, Derek Sim, Laurent O. Mosnier, Volker Laux
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2020-06-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-020-16720-9
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