Repurposing clinically safe drugs for DNA repair pathway choice in CRISPR genome editing and synthetic lethality
Abstract We evaluate the effect of most FDA-approved drugs (>7,000 conditions) on double-strand DNA break repair pathways by analyzing mutational outcomes in human induced pluripotent stem cells. We identify drugs that can be repurposed as inhibitors and enhancers of repair outcomes attributed to no...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2025-12-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-025-67243-0 |
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