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Multiple sclerosis lesions exhibit sex-specific steroid changes

Sex differences in disease susceptibility and progression in multiple sclerosis (MS) indicate hormonal influences. We previously found sex differences in steroidogenic enzyme expression in mixed active/inactive (mixed) and inactive lesions, suggesting increased synthesis and signalling of progestero...

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Principais autores: Sabina Luchetti, Matthew R.J. Mason, Philippe Liere, Antoine Pianos, Sara Cossu, Marloes Hofstee, Arja Sluiter, Adelia, Jackelien van Scheppingen, Eleonora Aronica, Michael Schumacher, Inge Huitinga
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-10-01
Serier:Neurobiology of Disease
Fag:
Neurosteroids
Allopregnanolone
Multiple sclerosis
GC/MS
Microglia
Astrocytes
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996125002566
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