Downregulation of ZBTB7A/LRF increases fetal hemoglobin expression in β0-thalassemia/hemoglobin E erythroid cells

Abstract Zinc finger and BTB domain-containing 7A (ZBTB7A) is a transcription factor repressor of fetal hemoglobin (HbF; α2γ2) in erythroid cells. Reactivating γ-globin expression represents a promising therapeutic strategy for β-hemoglobinopathies, including β-thalassemia. While ZBTB7A knockdown is...

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Bibliographic Details

Main Authors:	Sukanya Chumchuen, Tanapat Pornsukjantra, Pawarit Innachai, Pinyaphat Khamphikham, Chokdee Wongborisuth, Usanarat Anurathapan, Duantida Songdej, Orapan Sripichai, Amornrat Tangprasittipap, Suradej Hongeng
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2025-12-01
Series:	Scientific Reports
Subjects:	ZBTB7A/LRF Fetal hemoglobin (HbF) β-thalassemia/hemoglobin E
Online Access:	https://doi.org/10.1038/s41598-025-30762-3
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