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Intron retention enhances gene regulatory complexity in vertebrates

Abstract Background While intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied form of alternative splicing. To delineate conserved features of IR, we performed an exhaustive phylogenetic analysis in a highly purifi...

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Principais autores: Ulf Schmitz, Natalia Pinello, Fangzhi Jia, Sultan Alasmari, William Ritchie, Maria-Cristina Keightley, Shaniko Shini, Graham J. Lieschke, Justin J-L Wong, John E. J. Rasko
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-11-01
coleção:Genome Biology
Assuntos:
Transcriptomic complexity
Granulocytes
Evolution
Alternative splicing
Intron retention
Gene regulation
Acesso em linha:http://link.springer.com/article/10.1186/s13059-017-1339-3
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