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PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification. In cycling cells, the master regulator of ce...

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Principais autores: Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
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Acceso en liña:https://elifesciences.org/articles/80643
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