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Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery

This study delves into the impact of two synthetic non-natural amino acids, 7 and 8, on the structural dynamics of serum albumin and their potential significance in anticancer drug delivery systems. Crucially, the dihydrofuran-containing compound 7 has been identified to bind to the G-quadruplex (G4...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Hayarpi Simonyan, Rosanna Palumbo, Caterina Vicidomini, Pasqualina Liana Scognamiglio, Satenik Petrosyan, Lusine Sahakyan, Gagik Melikyan, Ashot Saghyan, Giovanni N. Roviello
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2025-06-01
Rangatū:Molecular Therapy: Nucleic Acids
Ngā marau:
MT: Oligonucleotides: Therapies and Applications
non-natural amino acids
asymmetric synthesis
heterocyclic compounds
c-Myc
G-quadruplex
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2162253125000320
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