Combining in vivo and in vitro studies to elucidate the inhibitory effect of resveratrol on vorolanib metabolism

IntroductionVorolanib is a new-generation multi-targeted kinase inhibitor (MTKI) whose drug-drug interaction (DDI) profile remains largely unexplored. This study combined in vitro and in vivo approaches to systematically investigate the effect of resveratrol on vorolanib metabolism.MethodsUsing ultr...

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Главные авторы:	Dongxin Chen, Hailun Xia, Lu Cao, Haoxin Fu, Yan Chen, Shiqi Jiang, Runjuan Zhan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-05-01
Серии:	Frontiers in Pharmacology
Предметы:	combination therapy drug-drug interactions pharmacokinetic resveratrol vorolanib
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1819774/full
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