Drug-tolerant persister cell in cancer: reversibility, microenvironmental interplay, and therapeutic strategies

Drug-tolerant persister (DTP) cells are a subpopulation of cancer cells capable of surviving therapeutic stress through reversible, non-genetic adaptations. These cells contribute to minimal residual disease and eventual tumor relapse. Understanding the mechanisms that govern the entry into and exit...

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Autores principales:	Haifeng Li, Wenlong Xu, Wenqi Cheng, Guanxiao Yu, Dongmei Tang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-08-01
Colección:	Frontiers in Pharmacology
Materias:	drug-tolerant persister (DTP) cells reversible drug resistance epigenetic and metabolic reprogramming tumor microenvironment (TME) therapeutic intervention strategies
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1612089/full
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