Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome

Abstract Background Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is an immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin is used for the treatment of type 2 diabetes and was reported to exert the...

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Autores principales:	Eun Kyung Kim, Hong Ki Min, Seon-Yeong Lee, Da-Som Kim, Jun-Geol Ryu, Hyun Sik Na, Kyoung Ah Jung, Jeong Won Choi, Sung-Hwan Park, Mi-La Cho
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2020-04-01
Colección:	Arthritis Research & Therapy
Materias:	Rheumatoid arthritis Obesity Mitochondria Metformin Rapamycin
Acceso en línea:	http://link.springer.com/article/10.1186/s13075-020-02174-3
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