Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

Behavioral recovery using (viable) peripheral nerve allografts to repair ablation-type (segmental-loss) peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal regeneration. Furthermore, such peripheral nerve allografts undergo immunological rejection by the host immune system...

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Bibliographic Details

Main Authors:	Tyler A. Smith, Liwen Zhou, Cameron L. Ghergherehchi, Michelle Mikesh, Cathy Z. Yang, Haley O. Tucker, JuliAnne Allgood, Jared S. Bushman, George D. Bittner
Format:	Artigo
Language:	Inglês
Published:	Wolters Kluwer Medknow Publications 2025-04-01
Series:	Neural Regeneration Research
Subjects:	allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol (peg) sciatic nerve t cell transplantation wallerian degeneration
Online Access:	https://journals.lww.com/10.4103/NRR.NRR-D-23-01220
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