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What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance

Abstract Background GPR65 is a pH-sensing G-protein-coupled receptor that acts as a key innate immune checkpoint in the human tumor microenvironment, inhibiting the release of inflammatory factors and inducing significant upregulation of tissue repair genes. However, the expression pattern and funct...

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Hlavní autoři: Jin Qi, Sihang Liu, Zhirui Zhang
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-01-01
Edice:Cancer Cell International
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On-line přístup:https://doi.org/10.1186/s12935-024-03216-5
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