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Hyaluronic acid fuels pancreatic cancer cell growth

Rewired metabolism is a hallmark of pancreatic ductal adenocarcinomas (PDA). Previously, we demonstrated that PDA cells enhance glycosylation precursor biogenesis through the hexosamine biosynthetic pathway (HBP) via activation of the rate limiting enzyme, glutamine-fructose 6-phosphate amidotransfe...

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Principais autores: Peter K Kim, Christopher J Halbrook, Samuel A Kerk, Megan Radyk, Stephanie Wisner, Daniel M Kremer, Peter Sajjakulnukit, Anthony Andren, Sean W Hou, Ayush Trivedi, Galloway Thurston, Abhinav Anand, Liang Yan, Lucia Salamanca-Cardona, Samuel D Welling, Li Zhang, Matthew R Pratt, Kayvan R Keshari, Haoqiang Ying, Costas A Lyssiotis
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2021-12-01
Colecção:eLife
Assuntos:
pancreatic cancer
tumor metabolism
tumor microenvironment
extracellular matrix
hyaluronic acid
hexosamine biosynthetic pathway
Acesso em linha:https://elifesciences.org/articles/62645
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