Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Abstract Background 18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351 retention in brain regions thought to contain negligible concentrations of PHF raise questions about the interpretation of the positron e...

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Principais autores:	Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie-Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean-Paul Soucy, Nobuyuki Okamura, Serge Gauthier, Pedro Rosa-Neto
格式:	Artigo
语言:	Inglês
出版:	BMC 2017-03-01
丛编:	Alzheimer’s Research & Therapy
主题:	18F-THK5351 tau tracer Monoamine oxidase-B Selegiline Alzheimer’s disease Positron emission tomography
在线阅读:	http://link.springer.com/article/10.1186/s13195-017-0253-y
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