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Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3β in the impairment of the NRF2 response

Friedreich ataxia (FA) is a rare neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Frataxin has been related in iron homeostasis, energy metabolism, and oxidative stress. Ferroptosis has recently been shown to be involved in FA cellular degeneration; however...

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Principais autores: Arabela Sanz-Alcázar, Marta Portillo-Carrasquer, Fabien Delaspre, Maria Pazos-Gil, Jordi Tamarit, Joaquim Ros, Elisa Cabiscol
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-10-01
Serier:Redox Biology
Fag:
Friedreich ataxia
Dorsal root ganglia
Ferroptosis
NRF2
LKB1/AMPK pathway
MT-6378
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213231724003173
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