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Estimating treatment sensitivity in synthetic and in vitro tumors using a random differential equation model

Abstract Resistance to treatment, which comes from the heterogeneity of cell types within tumors, is a leading cause of poor treatment outcomes in cancer patients. Previous mathematical work modeling cancer over time has neither emphasized the relationship between cell heterogeneity and treatment re...

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Principais autores: Natalie Meacham, Erica M. Rutter
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2025-05-01
Serija:npj Systems Biology and Applications
Online dostop:https://doi.org/10.1038/s41540-025-00530-0
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