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Long‐acting and extended‐release implant and nanoformulations with a synergistic antiretroviral two‐drug combination controls HIV‐1 infection in a humanized mouse model

Abstract The HIV pandemic has affected over 38 million people worldwide with close to 26 million currently accessing antiretroviral therapy (ART). A major challenge in the long‐term treatment of HIV‐1 infection is nonadherence to ART. Long‐acting antiretroviral (LA‐ARV) formulations, that reduce dos...

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Principais autores: Jagadish Beloor, Shalley N. Kudalkar, Gina Buzzelli, Fan Yang, Hanna K. Mandl, Jyothi K. Rajashekar, Krasimir A. Spasov, William L. Jorgensen, W. Mark Saltzman, Karen S. Anderson, Priti Kumar
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2022-01-01
Serier:Bioengineering & Translational Medicine
Fag:
Compound I
drug synergy
EFdA
HIV
humanized mice
implants
Online adgang:https://doi.org/10.1002/btm2.10237
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