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Optimal control theory as a method for designing multidrug adaptive therapy regimens

Abstract Evolutionarily informed regimens offer new approaches that hope to combat the development of resistance during cancer treatment. These regimens are often complicated to design. In this work, we use optimal control theory (OCT) to guide the design of a two-drug adaptive therapy regimen. We b...

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Библиографические подробности
Главные авторы: Afton Widdershins, Elsa Hansen, Andrew Read, Raymond Hohl
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Portfolio 2026-02-01
Серии:npj Systems Biology and Applications
Online-ссылка:https://doi.org/10.1038/s41540-025-00613-y
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