Assessment of drug permeability through an ex vivo porcine round window membrane model

Summary: Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear. Invasive surgeries to inject through the round window membrane (RWM) or coch...

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Principais autores:	Adele Moatti, Dylan Silkstone, Taylor Martin, Keith Abbey, Kendall A Hutson, Douglas C Fitzpatrick, Carlton J Zdanski, Alan G Cheng, Frances S Ligler, Alon Greenbaum
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2023-06-01
Series:	iScience
Assuntos:	Drug delivery system Health technology Membranes
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2589004223008660
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