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Mitigative effects of Otilonium Bromide on methotrexate-induced hepatic damage in rats

Abstract Objective Hepatotoxicity is a significant adverse effect associated with long-term methotrexate (MTX) treatment, limiting its clinical utility. This study aimed to comprehensively evaluate the potential hepatoprotective effects of Otilonium Bromide (OB) against MTX-induced liver injury in a...

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Autori principali: Murat Arı, Mumin Alper Erdogan, Oytun Erbaş
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-01-01
Serie:BMC Research Notes
Soggetti:
Fibrosis
Hepatotoxicity
Liver injury
Methotrexate
Otilonium bromide
Oxidative stress
Accesso online:https://doi.org/10.1186/s13104-025-07585-6
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