Human CAR Tregs Targeting SOD1 and Expressing BDNF Reduce Inflammation and Delay Disease in G93A hSOD1-NSG Mice

Regulatory T cells (Tregs) have anti-inflammatory immunomodulatory activity and hold therapeutic potential for chronic neuroinflammatory neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). We are developing engineered human Tregs with enhanced disease-modifying activity for trea...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	David J. Graber, W. James Cook, Marie-Louise Sentman, Joana M. Murad-Mabaera, Elijah W. Stommel, Charles L. Sentman
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2025-08-01
Sarja:	Cells
Aiheet:	amyotrophic lateral sclerosis regulatory T cell IL-10 inflammation cell therapy chimeric antigen receptor
Linkit:	https://www.mdpi.com/2073-4409/14/17/1318
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