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PARylation-centric crosstalk: orchestrating immune evasion and multidrug resistance in ovarian cancer

Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Beyond PARylation, diverse PTM networks—including ubiquitination, phosphorylation,...

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Principais autores: Lin Hou, Mengwen Zhang, Weihua Tong, Songling Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Immunology
Assuntos:
drug resistance
immunity of cancer
ovarian cancer
PARylation
post-translational modification
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1772562/full
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