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USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN

Background: Polycystic ovarian syndrome (PCOS) is an endocrine-related disease related to abnormal folliculogenesis and is a leading cause of infertility worldwide. Inhibition of granulosa cells (GCs) proliferation and increased GCs apoptosis have been identified as the major factors in aberrant fol...

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Principais autores: Yue Gao, Jiao Chen, Rui Ji, Jinli Ding, Yan Zhang, Jing Yang
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fcell.2021.779718/full
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