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Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model

IntroductionAdministration of dexamethasone (DEX) has been used experimentally to suppress androgenization of external genitalia in 46,XX fetuses with congenital adrenal hyperplasia. Despite this, the prenatal biological mechanism-of-action of DEX on fetal development is not known. This study aimed...

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Principais autores: Cecilie Melau, Berta Gayete Mor, Malene Lundgaard Riis, John E. Nielsen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Lea Langhoff Thuesen, Kristine Juul Hare, Rod T. Mitchell, Hanne Frederiksen, Anders Juul, Anne Jørgensen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-07-01
Serier:Frontiers in Endocrinology
Fag:
dexamethasone
ACTH-response
human fetal adrenals
ex vivo culture
steroidogenesis
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2023.1114211/full
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