Kinome inhibition reveals a role for polo‐like kinase 1 in targeting post‐transcriptional control in cancer

Dysfunctions in post‐transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3′‐untranslated region–AU‐rich elements (ARE). Fifteen inhibitors reduced the ARE‐reporter activity; among...

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Detalhes bibliográficos

Principais autores:	Qamraa H. Al‐Qahtani, Walid N. Moghrabi, Suhad Al‐Yahya, Latifa Al‐Haj, Maher Al‐Saif, Linah Mahmoud, Falah Al‐Mohanna, Norah Al‐Souhibani, Ayodele Alaiya, Edward Hitti, Khalid S. A. Khabar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2021-08-01
coleção:	Molecular Oncology
Assuntos:	AU‐rich elements kinase inhibitors mRNA decay post‐transcriptional control targeted therapy breast cancer
Acesso em linha:	https://doi.org/10.1002/1878-0261.12897
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