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TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response

Therapy-related clonal hematopoiesis (t-CH) is often observed in cancer survivors. This form of clonal hematopoiesis typically involves somatic mutations in driver genes that encode components of the DNA damage response and confer hematopoietic stem and progenitor cells (HSPCs) with resistance to th...

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Detalhes bibliográficos
Principais autores: Soichi Sano, Ying Wang, Hayato Ogawa, Keita Horitani, Miho Sano, Ariel H. Polizio, Anupreet Kour, Yoshimitsu Yura, Heather Doviak, Kenneth Walsh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2021-07-01
coleção:JCI Insight
Assuntos:
Acesso em linha:https://doi.org/10.1172/jci.insight.146076
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