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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Abstract Background Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21WAF1/Cip1, showing that its chronic expr...

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Principais autores: Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nickolaos N. Giakoumakis, Christina Glytsou, Ioannis S. Pateras, Umakanta Swain, Vassilis L. Souliotis, Alexandros G. Georgakilas, Nicholas Geacintov, Luca Scorrano, Claudia Lukas, Jiri Lukas, Zvi Livneh, Zoi Lygerou, Dipanjan Chowdhury, Claus Storgaard Sørensen, Jiri Bartek, Vassilis G. Gorgoulis
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-03-01
coleção:Genome Biology
Assuntos:
p21WAF1/Cip1
Rad52
Genomic instability
Translesion DNA synthesis (TLS)
Single nucleotide substitution (SNS)
Break-induced replication (BIR)
Acesso em linha:http://link.springer.com/article/10.1186/s13059-018-1401-9
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