Kallikrein–kinin system as a potential target for the treatment of intervertebral disc degeneration

Abstract Intervertebral disc degeneration (IVDD) is one of the main causes of chronic low back pain (LBP) and related spinal diseases, severely affecting patients’ quality of life and imposing a considerable burden on healthcare systems. Current treatment strategies for IVDD primarily include conser...

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Hlavní autoři:	Tong Lu, Wei Zhu, Fangjun Yang, Kai Zhu, Jiayu Ren, Huanping Zhu, Binglin Ye, Fengqi Sun, Wanqian Zhang, Xiaoming Qiu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-11-01
Edice:	European Journal of Medical Research
Témata:	Intervertebral disc degeneration Kallikrein–kinin system Bradykinin 1 receptor Bradykinin 2 receptor Inflammation Oxidative stress
On-line přístup:	https://doi.org/10.1186/s40001-025-03341-5
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