Human endogenous retroviruses in schizophrenia: clinical evidence, molecular mechanisms, and implications

Human endogenous retroviruses (HERVs), comprising 8% of the human genome, are implicated in schizophrenia, a complex psychiatric disorder driven by genetic, epigenetic, and environmental factors. This review examines the role of HERVs in schizophrenia pathogenesis. We synthesized clinical evidence,...

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Detalhes bibliográficos
Main Authors: Mengyu Zhang, Xiaoge Wang, Yun Liu, Chenxuan Bao, Qing Gao, Lingxiang Mao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
Colecção:Frontiers in Cellular and Infection Microbiology
Assuntos:
human endogenous retroviruses
schizophrenia
neuroinflammation
gene-environment interactions
synaptic dysfunction
precision psychiatry
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1677212/full
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