Differential Toxicity of DNA Adducts of Mitomycin C
The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This review focuses on differential biological effects of individual adducts in various mammalian cell cultures, observed in the authors' laboratories. Evid...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Wiley
2010-01-01
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| Serier: | Journal of Nucleic Acids |
| Online adgang: | http://dx.doi.org/10.4061/2010/698960 |
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