Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

PrPSc, a misfolded, aggregation-prone isoform of the cellular prion protein (PrPC), is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other mammals. PrPSc can adopt different pathogenic conformations (prion strains), which can be resistant to potential drug...

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Bibliografske podrobnosti

Principais autores:	Antonio Masone, Chiara Zucchelli, Enrico Caruso, Giovanna Musco, Roberto Chiesa
Format:	Artigo
Jezik:	Inglês
Izdano:	Wolters Kluwer Medknow Publications 2025-04-01
Serija:	Neural Regeneration Research
Teme:	anti-prion drug anti-prpc antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease prpc degrader prpc shedding zinc finger repressor
Online dostop:	https://journals.lww.com/10.4103/NRR.NRR-D-24-00181
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