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Clinical efficacy and safety of umbralisib, a dual PI3Kδ/CK1-ϵ inhibitor, in treatment of hematologic malignancies

BackgroundUmbralisib, a dual PI3Kδ/CK-1ϵ inhibitor, has shown clinical activity in various hematologic malignancies. However, a systematic assessment of its efficacy and safety is still lacking. This study provides a comprehensive evaluation based on current clinical evidence.MethodsA comprehensive...

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Principais autores: Yunke Zang, Hai-en Cheng, Yanhua Sun, Jingfei Wang, Yuying Zhao, Jingning Yang, Yongping Liu, Yanli Sun
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-01-01
Serier:Frontiers in Oncology
Fag:
casein kinase-1 ϵ
efficacy
hematologic malignancies
phosphoinositide-3-kinase δ
safety
umbralisib
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2025.1591759/full
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