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Calmodulin D133H Disrupts Ca<sub>v</sub>1.2 and K<sub>v</sub>7.1 Regulation to Prolong Cardiac Action Potentials in Long QT Syndrome

Calmodulin (CaM) plays a central role in cardiac excitation–contraction coupling by regulating ion channels, including the L-type calcium (Ca<sup>2+</sup>) channel Ca<sub>v</sub>1.2 and the voltage-gated potassium (K<sup>+</sup>) channel K<sub>v</sub>7.1. Mutations in CaM are linked to severe arrhyt...

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Hoofdauteurs: Nitika Gupta, Liam F. McCormick, Ella M. B. Richards, Kirsty Wadmore, Rachael Morris, Vanessa S. Morris, Pavel Kirilenko, Ewan D. Fowler, Caroline Dart, Nordine Helassa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2025-11-01
Reeks:Cells
Onderwerpen:
calmodulin
D133H mutation
long QT syndrome
cardiac arrhythmia
Ca<sub>v</sub>1.2 (L-type calcium channel)
K<sub>v</sub>7.1 (KCNQ1 potassium channel)
Online toegang:https://www.mdpi.com/2073-4409/14/22/1763
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