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Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish

The functions of PTEN (phosphatase/tensin homolog)-induced putative kinase (PINK1), which is mutated in early-onset Parkinson's disease, are poorly understood. We characterized a PINK1 antibody and found colocalization of PINK1-like immunoreactivity with aminergic markers. We inactivated translation...

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Principais autores: Ville Sallinen, Juha Kolehmainen, Madhusmita Priyadarshini, Gabija Toleikyte, Yu-Chia Chen, Pertti Panula
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2010-10-01
Serier:Neurobiology of Disease
Fag:
Parkinson's disease
Park6
Neurodegeneration
Tyrosine hydroxylase
Dopamine
Translation inhibition
Online adgang:http://www.sciencedirect.com/science/article/pii/S096999611000197X
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