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Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis

Red blood cell (RBC) deformability is altered in inherited RBC disorders but the mechanism behind this is poorly understood. Here, we explored the molecular, biophysical, morphological, and functional consequences of α-spectrin mutations in a patient with hereditary elliptocytosis (pEl) almost exclu...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Hélène Pollet, Anne-Sophie Cloos, Amaury Stommen, Juliette Vanderroost, Louise Conrard, Adrien Paquot, Marine Ghodsi, Mélanie Carquin, Catherine Léonard, Manuel Guthmann, Maxime Lingurski, Christiane Vermylen, Theodore Killian, Laurent Gatto, Mark Rider, Sébastien Pyr dit Ruys, Didier Vertommen, Miikka Vikkula, Pascal Brouillard, Patrick Van Der Smissen, Giulio G. Muccioli, Donatienne Tyteca
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2020-07-01
Rangatū:Biomolecules
Ngā marau:
spectrin cytoskeleton
Ca<sup>2+</sup>
lipid domains
membrane asymmetry
membrane rigidity
membrane curvature
Urunga tuihono:https://www.mdpi.com/2218-273X/10/8/1120
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