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Integrated transcriptomics unveils mitochondrial oxidative phosphorylation dysfunction as a shared mechanism in sarcopenia and obesity

Abstract Sarcopenia and obesity, two prevalent metabolic disorders in aging populations, often coexist and share overlapping pathophysiological mechanisms, yet the molecular mechanisms underlying their comorbidity remain elusive. This study aimed to identify key gene expression signatures and pathwa...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ruixuan Yu, Lei Miao, Jinchao Wang, Dingding Wang, Yajun Liu, Ling Wang, Renxian Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-10-01
Schriftenreihe:Scientific Reports
Schlagworte:
Sarcopenia
Obesity
Bioinformatics
Mitochondrial dysfunction
Oxidative phosphorylation
Online-Zugang:https://doi.org/10.1038/s41598-025-18824-y
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