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MR analysis reveals no causal association between mitochondrial DNA copy number and osteoporosis

Abstract Observational studies have suggested a connection between mitochondrial DNA copy number (mtDNA-CN) and osteoporosis, but the causal role of mtDNA-CN remains uncertain. This study aimed to elucidate the causal association between mtDNA-CN and osteoporosis using a two-sample Mendelian randomi...

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Principais autores: Misu Xiao, Cheng Guo, Quanjun Yang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-07-01
Serier:Scientific Reports
Fag:
Mitochondrial DNA copy number
Osteoporosis
Mendelian randomization
Causal relationship
Genome-wide association studies
Online adgang:https://doi.org/10.1038/s41598-025-05287-4
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