Paradoxical whole genome DNA methylation dynamics of 5’aza-deoxycytidine in chronic low-dose exposure in mice

Decitabine (5-aza-2ʹdeoxycytidine; DAC) is a DNA methyltransferase inhibitor used to hypomethylate the epigenome. Current dosing regimens of DAC for use in mice vary widely and their hypomethylating ability has not been robustly characterized, despite reliable results of hypomethylation of the epige...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Mathia Colwell, Nicole M. Wanner, Chelsea Drown, Melissa Drown, Dana C. Dolinoy, Christopher Faulk
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Taylor & Francis Group 2021-02-01
Sarja:	Epigenetics
Aiheet:	decitabine dna methylation epigenetics chronic low-dose whole genome bisulfite sequencing transcriptome
Linkit:	http://dx.doi.org/10.1080/15592294.2020.1790951
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