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Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity

Abstract Background Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mitochondrial targeting activities. Herein, we investigated the capabilit...

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Päätekijät: Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande, Nicola Amodio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2024-02-01
Sarja:Journal of Translational Medicine
Aiheet:
Flavanones
Hesperitin
Naringenin
Mitochondrial dynamics
Multiple myeloma
Linkit:https://doi.org/10.1186/s12967-024-05013-0
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