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Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive tract tumor with limited clinical treatments. Transforming acidic coiled-coil-containing protein 3 (TACC3) is a component of the centrosome axis and a member of the TACC family, which affect mitosis and regulate chromos...

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Hlavní autoři: Saimeng Shi, Duancheng Guo, Longyun Ye, Tianjiao Li, Qinglin Fei, Mengxiong Lin, Xianjun Yu, Kaizhou Jin, Weiding Wu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2023-11-01
Edice:Cell Death and Disease
On-line přístup:https://doi.org/10.1038/s41419-023-06313-x
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