Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity

Background: Methotrexate (MTX) is an effective anticancer, anti-inflammatory, and immunomodulatory agent. However, it induces a serious pneumonitis that leads to irreversible fibrotic lung damage. This study addresses the protective role of the natural flavonoid dihydromyricetin (DHM) against MTX-in...

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Bibliografske podrobnosti

Principais autores:	Asmaa I. Matouk, Eman M. Awad, Nashwa F. G. El-Tahawy, Azza A. K. El-Sheikh, Aliaa Anter
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2023-03-01
Serija:	Pharmaceuticals
Teme:	methotrexate dihydromyricetin NF-κB Nrf2 HO-1 IL-1β
Online dostop:	https://www.mdpi.com/1424-8247/16/4/481
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