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Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity

Summary: Characterization of I37R, a mutation located in the lasso motif of the CFTR chloride channel, was conducted by theratyping several CFTR modulators from both potentiator and corrector classes. Intestinal current measurements in rectal biopsies, forskolin-induced swelling (FIS) in intestinal...

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Principais autores: Sharon L. Wong, Nikhil T. Awatade, Miro A. Astore, Katelin M. Allan, Michael J. Carnell, Iveta Slapetova, Po-chia Chen, Alexander Capraro, Laura K. Fawcett, Renee M. Whan, Renate Griffith, Chee Y. Ooi, Serdar Kuyucak, Adam Jaffe, Shafagh A. Waters
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-01-01
Serier:iScience
Fag:
Pharmacology
Biochemistry
Structural biology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004221016801
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